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K Higuchi Selected Research

sphingomyelin deacylase

10/2001Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes.
9/2000The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
9/2000High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.

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K Higuchi Research Topics

Disease

13Neoplasms (Cancer)
02/2017 - 02/2000
12Ulcer
10/2014 - 01/2000
12Infections
09/2012 - 01/2000
9Stomach Ulcer (Gastric Ulcer)
02/2007 - 01/2000
6Amyloidosis
03/2014 - 08/2000
6Tuberculosis (Tuberculoses)
09/2012 - 08/2000
4Gastroesophageal Reflux (GERD)
01/2018 - 04/2002
4Dyspepsia (Indigestion)
01/2018 - 01/2002
4Hemorrhage
10/2014 - 04/2000
4Gastritis
01/2004 - 04/2000
3Body Weight (Weight, Body)
02/2017 - 02/2000
3Stomach Neoplasms (Stomach Cancer)
01/2015 - 01/2008
3Peptic Ulcer (Peptic Ulcers)
10/2014 - 01/2004
3Inflammation (Inflammations)
03/2014 - 01/2001
3Necrosis
02/2008 - 06/2001
3Cicatrix (Scar)
12/2006 - 06/2001
3Atrophy
07/2006 - 12/2000
3Colonic Neoplasms (Colon Cancer)
07/2004 - 09/2001
3Atopic Dermatitis (Atopic Eczema)
10/2001 - 09/2000
3Uterine Cervical Neoplasms (Cancer of the Cervix)
10/2000 - 07/2000
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
06/2018 - 09/2001
2Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
01/2018 - 02/2017
2Disease Progression
10/2016 - 08/2009
2Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
08/2009 - 01/2003
2Neoplasm Metastasis (Metastasis)
01/2008 - 01/2007
2Hyperplasia
04/2006 - 04/2002
2Crohn Disease (Crohn's Disease)
10/2005 - 05/2003
2Ganglion Cysts (Ganglion)
12/2000 - 11/2000
1Pathologic Constriction (Stenosis)
03/2020
1Dental Calculus
06/2018
1Diarrhea
02/2017
1Mucositis
02/2017
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
10/2016

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
10/2016 - 07/2000
7AcidsIBA
04/2006 - 06/2001
6Interferon-gamma (Interferon, gamma)IBA
09/2012 - 08/2000
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2018 - 01/2000
5Amyloid (Amyloid Fibrils)IBA
03/2014 - 08/2000
4Famotidine (Pepcid)FDA LinkGeneric
02/2017 - 01/2005
4GoldIBA
09/2012 - 09/2007
4Apolipoprotein A-II (Apolipoprotein A2)IBA
06/2011 - 09/2000
4CytokinesIBA
05/2008 - 01/2001
4AntibodiesIBA
02/2008 - 11/2000
4Pharmaceutical PreparationsIBA
02/2007 - 01/2000
3Rabeprazole (Aciphex)FDA Link
10/2014 - 05/2008
3Proton Pump InhibitorsIBA
10/2013 - 01/2003
3Anti-Bacterial Agents (Antibiotics)IBA
02/2008 - 03/2001
3Peroxidase (Myeloperoxidase)IBA
07/2003 - 01/2000
3sphingomyelin deacylaseIBA
10/2001 - 09/2000
3Acetic Acid (Vinegar)FDA LinkGeneric
02/2001 - 01/2000
2lafutidineIBA
02/2017 - 12/2006
2Cisplatin (Platino)FDA LinkGeneric
01/2015 - 01/2007
2Omeprazole (Prilosec)FDA LinkGeneric
06/2010 - 06/2005
2Amoxicillin (Wymox)FDA LinkGeneric
06/2010 - 01/2003
2Clarithromycin (Biaxin)FDA LinkGeneric
06/2010 - 01/2003
2Coloring Agents (Dyes)IBA
09/2009 - 12/2006
2SteroidsIBA
08/2009 - 11/2002
2Inosine Triphosphate (ITP)IBA
08/2009 - 01/2003
2LigandsIBA
02/2008 - 09/2001
2Biological ProductsIBA
01/2008 - 01/2004
2Interleukin-10 (Interleukin 10)IBA
01/2008 - 01/2001
2InterleukinsIBA
01/2008 - 01/2001
2AntigensIBA
09/2007 - 08/2001
2N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA
06/2007 - 07/2004
2Tacrolimus (Prograf)FDA LinkGeneric
07/2006 - 07/2006
2BombesinIBA
07/2006 - 07/2006
2NeuropeptidesIBA
07/2006 - 07/2006
2Peptides (Polypeptides)IBA
03/2005 - 04/2000
2Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2004 - 01/2000
2Messenger RNA (mRNA)IBA
09/2001 - 02/2001
2Immunoglobulin G (IgG)IBA
06/2001 - 01/2001
2Cell Adhesion MoleculesIBA
06/2001 - 05/2000
2Retinaldehyde (Retinal)IBA
12/2000 - 11/2000
2EnzymesIBA
09/2000 - 09/2000
2SphingomyelinsIBA
09/2000 - 09/2000
2Caseins (Casein)FDA Link
08/2000 - 01/2000
1MetalsIBA
03/2020
1InflammasomesIBA
06/2018
1benzyloxycarbonyltyrosyl- valyl- alanyl- aspartic acid fluoromethyl ketoneIBA
06/2018
1Durapatite (Hydroxylapatite)IBA
06/2018
1Glyburide (Glibenclamide)FDA LinkGeneric
06/2018
1Cytochalasin DIBA
06/2018
1Propidium (Propidium Iodide)IBA
06/2018
1NucleotidesIBA
06/2018
14-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA
01/2018
1liu-jun-zi-tangIBA
01/2018
1Fluorouracil (Carac)FDA LinkGeneric
02/2017
1AntacidsIBA
02/2017
1Histamine H2 AntagonistsIBA
02/2017
1ParaffinIBA
10/2016
1Formaldehyde (Formol)FDA Link
10/2016
1DNA-Binding Proteins (DNA Binding Protein)IBA
10/2016

Therapy/Procedure

9Therapeutics
10/2014 - 01/2000
3Drug Therapy (Chemotherapy)
02/2017 - 11/2000
3Aftercare (After-Treatment)
01/2008 - 01/2004
2Stents
03/2020 - 05/2003
2Intraperitoneal Injections
01/2008 - 01/2000
2Transplantation
07/2006 - 07/2006
2Ligation
04/2002 - 11/2001
1Pancreaticojejunostomy
03/2020